Weight Loss Led To Reduction In Inflammation

Insulin status is important determinant of weight reduction on vascular function

Women in the trial who were assigned to a weight loss intervention had a goal of 10 percent weight reduction during the course of one year achieved through a diet intervention with or without aerobic exercise . “So this program was highly achievable and reproducible. We are not talking about drastic weight loss,” said McTiernan. The researchers measured levels of C-reactive protein, serum amyloid A, interleukin-6, leukocyte and neutrophil in 439 women. At the end of one year, C-reactive protein reduced by 36.1 percent in the diet-alone group and by 41.7 percent in the diet and exercise group. Interleukin-6 decreased by 23.1 percent in the diet group and 24.3 percent in the diet and exercise group. McTiernan and colleagues found a mild dose response, as there were greater reductions in these measures among women who lost at least 5 percent of their body weight.
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and worldwide with nearly 70 percent of the U.S. population currently overweight or obese. Of major concern are the disproportionate cases of severe obesity ( body mass index [BMI] ? 40 kg/m2), which tripled during the 1990s. Nearly a third of adults and 17 percent of children in the U.S. are now obese with 65 million additional cases estimated by 2030. While obesity confers serious health concerns and increased all-cause mortality, the vast majority of deaths are due to cardiovascular causes such as ischemic heart disease Garcinia Cambogia Extract and stroke.
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Report: Mazda Targets 700-pound Weight Reduction for Next Gen Miata

The reduction in fuel consumption for its models would mostly come from a reduction in weight for its next generation models and reduced dimensions of its vehicles (with a few rare exceptions, when a next generation of a vehicle is introduced, it is often larger and heavier than the model it replaces). Mazda is looking to remove an extraordinary amount of weight from the next generation MX-5 (better known as the Miata in North America). The NC (third generation) Miata isn’t exactly a pig, as it weighs 2,480 pounds with a 5-speed manual and 2,511 pounds with a 6-speed manual. However, this is over 300 pounds heavier than the NA (first generation) Miata which tipped the scales at 2,116 pounds. According to The Car Connection, Mazda’s current goal for the next generation Miata is to cut weight by 720 pounds. That would put a base Miata at just under 1,800 pounds — an almost unheard low for North American market vehicles. For comparison, the aluminum-intensive Lotus Elise tips the scales at 2,010 pounds.
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